![]() ![]() ![]() This reduces neuronal excitability, with a hypnotic, anxiolytic and anticonvulsive effect as a result (4, 5).īenzodiazepines can also be used as intoxicants, and have adverse long-term effects in the form of impaired cognitive abilities and risk of dependence. Since the 1990s, z-hypnotics such as zopiclone (Imovane, Zopitin) and zolpidem (Stilnoct), have taken over for insomnia (3).īenzodiazepines and z-hypnotics are chemically dissimilar, but both act by increasing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) on GABA A receptors in the brain. ![]() In 2008, 6 % of the Norwegian population was prescribed at least one benzodiazepine (2). The use of benzodiazepines has increased sharply since they were first synthesised in the 1950s, and they have gradually replaced barbiturates and other hypnotic and anti-anxiety drugs (1). ![]()
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